Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Conventional efforts relying on high-throughput physical and virtual screening of large compound libraries have failed to yield high-efficiency chemical probes for many of the 48 human nuclear receptors. Here, we investigated whether disulfide-trapping, an approach new to nuclear receptors, would pr...

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Vydáno v:PLoS One
Hlavní autoři: de Jesus Cortez, Felipe, Suzawa, Miyuki, Irvy, Sam, Bruning, John M., Sablin, Elena, Jacobson, Matthew P., Fletterick, Robert J., Ingraham, Holly A., England, Pamela M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965143/
https://ncbi.nlm.nih.gov/pubmed/27467220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159316
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