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Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1
A regulatory circuit that controls myeloid versus B lymphoid cell fate in hematopoietic progenitors has been proposed, in which a network of the transcription factors Egr1/2, Nab, Gfi1 and PU.1 forms the core element. Here we show that a direct link between Gfi1, the transcription factor E2A and its...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4965025/ https://ncbi.nlm.nih.gov/pubmed/27467586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160344 |
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