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Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372. In human myeloid leukemia, low GFI1 levels correlate with an inferior prognosis. Here, we show that knockdown (KD) of G...
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| Publicado no: | Leukemia |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6326955/ https://ncbi.nlm.nih.gov/pubmed/29925903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0166-1 |
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