Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)

NCX1 (Na(+)/Ca(2+) exchanger 1) is an important regulator of intracellular Ca(2+) and a potential therapeutic target for brain ischaemia and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1...

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Bibliographic Details
Published in:Biochem J
Main Authors: Wanichawan, Pimthanya, Hodne, Kjetil, Hafver, Tandekile Lubelwana, Lunde, Marianne, Martinsen, Marita, Louch, William Edward, Sejersted, Ole Mathias, Carlson, Cathrine Rein
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964977/
https://ncbi.nlm.nih.gov/pubmed/27247424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160465
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