Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progeni...

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Publicado en:eLife
Autores principales: Zheng, Xinde, Boyer, Leah, Jin, Mingji, Mertens, Jerome, Kim, Yongsung, Ma, Li, Hamm, Michael, Gage, Fred H, Hunter, Tony
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963198/
https://ncbi.nlm.nih.gov/pubmed/27282387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13374
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