Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected but important bioenergetic effect of mTOR inhibition in neurons. mTOR inhibition by rapamycin significantly preserve...

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Udgivet i:eLife
Main Authors: Zheng, Xinde, Boyer, Leah, Jin, Mingji, Kim, Yongsung, Fan, Weiwei, Bardy, Cedric, Berggren, Travis, Evans, Ronald M, Gage, Fred H, Hunter, Tony
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846388/
https://ncbi.nlm.nih.gov/pubmed/27008180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13378
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