Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progeni...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Zheng, Xinde, Boyer, Leah, Jin, Mingji, Mertens, Jerome, Kim, Yongsung, Ma, Li, Hamm, Michael, Gage, Fred H, Hunter, Tony
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Developmental Biology and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963198/
https://ncbi.nlm.nih.gov/pubmed/27282387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13374
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