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Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and “BRCA-Like” Status, in Both Blood and Tumour DNA

Triple negative breast cancer is typically an aggressive and difficult to treat subtype. It is often associated with loss of function of the BRCA1 gene, either through mutation, loss of heterozygosity or methylation. This study aimed to measure methylation of the BRCA1 gene promoter at individual Cp...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Daniels, Sarah L., Burghel, George J., Chambers, Philip, Al-Baba, Shadi, Connley, Daniel D., Brock, Ian W., Cramp, Helen E., Dotsenko, Olena, Wilks, Octavia, Wyld, Lynda, Cross, Simon S., Cox, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963032/
https://ncbi.nlm.nih.gov/pubmed/27463681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160174
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