Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels

PURPOSE: Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actio...

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Publicat a:J Clin Oncol
Autors principals: Stadler, Zsofia K., Battaglin, Francesca, Middha, Sumit, Hechtman, Jaclyn F., Tran, Christina, Cercek, Andrea, Yaeger, Rona, Segal, Neil H., Varghese, Anna M., Reidy-Lagunes, Diane L., Kemeny, Nancy E., Salo-Mullen, Erin E., Ashraf, Asad, Weiser, Martin R., Garcia-Aguilar, Julio, Robson, Mark E., Offit, Kenneth, Arcila, Maria E., Berger, Michael F., Shia, Jinru, Solit, David B., Saltz, Leonard B.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2016
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ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962706/
https://ncbi.nlm.nih.gov/pubmed/27022117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.65.1067
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