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3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats

Disruption of the homeostasis of oxygenated regulatory lipid mediators (oxylipins), potential markers of exposure to aryl hydrocarbon receptor (AhR) agonists, such as 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), is associated with a range of diseases, including nonalcoholic fatty liver disease and non...

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Détails bibliographiques
Publié dans:Toxicol Sci
Auteurs principaux: Wu, Xianai, Yang, Jun, Morisseau, Christophe, Robertson, Larry W., Hammock, Bruce, Lehmler, Hans-Joachim
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960907/
https://ncbi.nlm.nih.gov/pubmed/27208083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw084
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