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Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake. SREBP cleavage activating protein (SCAP) plays an essential role...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Shao (邵威), Wei, Machamer, Carolyn E., Espenshade, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959871/
https://ncbi.nlm.nih.gov/pubmed/27324795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M069583
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