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SAHA-induced loss of the tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model

Thyroid cancer is on the rise. Novel approaches are needed to improve the outcome of patients with recurrent and advanced metastatic thyroid cancers. FDA approval of suberoylanilide hydroxamic acid (SAHA; vorinostat), an inhibitor of histone deacetylase, for the treatment of hematologic malignancies...

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Bibliographic Details
Published in:Endocr Relat Cancer
Main Authors: Zhu, Xuguang, Kim, Dong Wook, Zhao, Li, Willingham, Mark C., Cheng, Sheue-yann
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959547/
https://ncbi.nlm.nih.gov/pubmed/27267120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-16-0103
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