Dexamethasone Induces Cardiomyocyte Terminal Differentiation via Epigenetic Repression of Cyclin D2 Gene

Dexamethasone treatment of newborn rats inhibited cardiomyocyte proliferation and stimulated premature terminal differentiation of cardiomyocytes in the developing heart. Yet mechanisms remain undetermined. The present study tested the hypothesis that the direct effect of glucocorticoid receptor-med...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Gay, Maresha S., Dasgupta, Chiranjib, Li, Yong, Kanna, Angela, Zhang, Lubo
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2016
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959091/
https://ncbi.nlm.nih.gov/pubmed/27302109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.234104
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