Dexamethasone Induces Cardiomyocyte Terminal Differentiation via Epigenetic Repression of Cyclin D2 Gene

Dexamethasone treatment of newborn rats inhibited cardiomyocyte proliferation and stimulated premature terminal differentiation of cardiomyocytes in the developing heart. Yet mechanisms remain undetermined. The present study tested the hypothesis that the direct effect of glucocorticoid receptor-med...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Gay, Maresha S., Dasgupta, Chiranjib, Li, Yong, Kanna, Angela, Zhang, Lubo
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959091/
https://ncbi.nlm.nih.gov/pubmed/27302109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.234104
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