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Dexamethasone Treatment of Newborn Rats Decreases Cardiomyocyte Endowment in the Developing Heart through Epigenetic Modifications

The potential adverse effect of synthetic glucocorticoid, dexamethasone therapy on the developing heart remains unknown. The present study investigated the effects of dexamethasone on cardiomyocyte proliferation and binucleation in the developing heart of newborn rats and evaluated DNA methylation a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gay, Maresha S., Li, Yong, Xiong, Fuxia, Lin, Thant, Zhang, Lubo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414482/
https://ncbi.nlm.nih.gov/pubmed/25923220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125033
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