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Estimating Mutation Load in Human Genomes

Next-generation sequencing technology has facilitated the discovery of millions of variants in human genomes. A sizeable fraction of these alleles are thought to be deleterious. We review the pattern of deleterious alleles as ascertained in genomic data and ask whether human populations differ in th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Genet
Prif Awduron: Henn, Brenna M., Botigué, Laura R., Bustamante, Carlos D., Clark, Andrew G., Gravel, Simon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959039/
https://ncbi.nlm.nih.gov/pubmed/25963372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3931
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