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Estimating Mutation Load in Human Genomes

Next-generation sequencing technology has facilitated the discovery of millions of variants in human genomes. A sizeable fraction of these alleles are thought to be deleterious. We review the pattern of deleterious alleles as ascertained in genomic data and ask whether human populations differ in th...

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Detalles Bibliográficos
Publicado en:Nat Rev Genet
Autores principales: Henn, Brenna M., Botigué, Laura R., Bustamante, Carlos D., Clark, Andrew G., Gravel, Simon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959039/
https://ncbi.nlm.nih.gov/pubmed/25963372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3931
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