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Estimating Mutation Load in Human Genomes
Next-generation sequencing technology has facilitated the discovery of millions of variants in human genomes. A sizeable fraction of these alleles are thought to be deleterious. We review the pattern of deleterious alleles as ascertained in genomic data and ask whether human populations differ in th...
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| Publicado en: | Nat Rev Genet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959039/ https://ncbi.nlm.nih.gov/pubmed/25963372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3931 |
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