Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been approved for marketing or are currently in clinical development. We undertook an analysis of the kinetics of the in vitro responses of Plasmodium falciparum to the new oz...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958167/
https://ncbi.nlm.nih.gov/pubmed/27161632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00574-16
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