On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal(1). In various pathophysiological conditions, however, erythrocyte life span is severely comp...

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Pubblicato in:Nat Med
Autori principali: Theurl, Igor, Hilgendorf, Ingo, Nairz, Manfred, Tymoszuk, Piotr, Haschka, David, Asshoff, Malte, He, Shun, Gerhardt, Louisa M. S., Holderried, Tobias A. W., Seifert, Markus, Sopper, Sieghart, Fenn, Ashley M., Anzai, Atsushi, Rattik, Sara, McAlpine, Cameron, Theurl, Milan, Wieghofer, Peter, Iwamoto, Yoshiko, Weber, Georg F., Harder, Nina K., Chousterman, Benjamin G., Arvedson, Tara L., McKee, Mary, Wang, Fudi, Lutz, Oliver M. D., Rezoagli, Emanuele, Babitt, Jodie L., Berra, Lorenzo, Prinz, Marco, Nahrendorf, Matthias, Weiss, Guenter, Weissleder, Ralph, Lin, Herbert Y., Swirski, Filip K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957133/
https://ncbi.nlm.nih.gov/pubmed/27428900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4146
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