On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal(1). In various pathophysiological conditions, however, erythrocyte life span is severely comp...

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Publicado no:Nat Med
Main Authors: Theurl, Igor, Hilgendorf, Ingo, Nairz, Manfred, Tymoszuk, Piotr, Haschka, David, Asshoff, Malte, He, Shun, Gerhardt, Louisa M. S., Holderried, Tobias A. W., Seifert, Markus, Sopper, Sieghart, Fenn, Ashley M., Anzai, Atsushi, Rattik, Sara, McAlpine, Cameron, Theurl, Milan, Wieghofer, Peter, Iwamoto, Yoshiko, Weber, Georg F., Harder, Nina K., Chousterman, Benjamin G., Arvedson, Tara L., McKee, Mary, Wang, Fudi, Lutz, Oliver M. D., Rezoagli, Emanuele, Babitt, Jodie L., Berra, Lorenzo, Prinz, Marco, Nahrendorf, Matthias, Weiss, Guenter, Weissleder, Ralph, Lin, Herbert Y., Swirski, Filip K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957133/
https://ncbi.nlm.nih.gov/pubmed/27428900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4146
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