Vismodegib or Cixutumumab in Combination With Standard Chemotherapy for Patients With Extensive-Stage Small Cell Lung Cancer: A Trial of the ECOG-ACRIN Cancer Research Group (E1508)

BACKGROUND: Preclinical targeting of the hedgehog pathway by vismodegib and of insulin-like growth factor 1 receptor by cixutumumab enhances the efficacy of chemotherapy and also demonstrates activity against the tumor cell fraction responsible for disease recurrence in small cell lung cancer. METHO...

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Gepubliceerd in:Cancer
Hoofdauteurs: Belani, Chandra P., Dahlberg, Suzanne E., Rudin, Charles M., Fleisher, Martin, Chen, Helen X., Takebe, Naoko, Velasco, Mario R., Tester, William J., Sturtz, Keren, Hann, Christine L., Shanks, James C., Monga, Manish, Ramalingam, Suresh S., Schiller, Joan H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956531/
https://ncbi.nlm.nih.gov/pubmed/27163943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30062
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