A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E2511)

OBJECTIVES: Veliparib (V) potentiated therapeutic efficacy of cisplatin (C) and etoposide (E) in preclinical models of SCLC. We conducted this phase 1 study to establish the safety of the combination in human subjects. MATERIALS AND METHODS: The study employed the 3+3 dose escalation design to estab...

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Veröffentlicht in:Lung Cancer
Hauptverfasser: Owonikoko, Taofeek K., Dahlberg, Suzanne E., Khan, Saad A., Gerber, David E., Dowell, Jonathan, Moss, Rebecca A., Belani, Chandra P., Hann, Christine L., Aggarwal, Charu, Ramalingam, Suresh S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539011/
https://ncbi.nlm.nih.gov/pubmed/25985977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2015.04.015
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