Vismodegib or Cixutumumab in Combination With Standard Chemotherapy for Patients With Extensive-Stage Small Cell Lung Cancer: A Trial of the ECOG-ACRIN Cancer Research Group (E1508)

BACKGROUND: Preclinical targeting of the hedgehog pathway by vismodegib and of insulin-like growth factor 1 receptor by cixutumumab enhances the efficacy of chemotherapy and also demonstrates activity against the tumor cell fraction responsible for disease recurrence in small cell lung cancer. METHO...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Belani, Chandra P., Dahlberg, Suzanne E., Rudin, Charles M., Fleisher, Martin, Chen, Helen X., Takebe, Naoko, Velasco, Mario R., Tester, William J., Sturtz, Keren, Hann, Christine L., Shanks, James C., Monga, Manish, Ramalingam, Suresh S., Schiller, Joan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956531/
https://ncbi.nlm.nih.gov/pubmed/27163943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30062
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