Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2

FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction. Here we demonstrate the persistent and essential role of FGF21 in the metabolic response to protein restriction. We show...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Laeger, Thomas, Albarado, Diana C., Burke, Susan J., Trosclair, Lexus, Hedgepeth, John W., Berthoud, Hans-Rudolf, Gettys, Thomas W., Collier, J. Jason, Münzberg, Heike, Morrison, Christopher D.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956501/
https://ncbi.nlm.nih.gov/pubmed/27396336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.044
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