FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor bKlotho (Klb) from the brain produces mice that are unable to mount a physiological response t...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Hill, Cristal M., Laeger, Thomas, Dehner, Madeleine, Albarado, Diana C., Clarke, Blaise, Wanders, Desiree, Burke, Susan J., Collier, J. Jason, Qualls-Creekmore, Emily, Solon-Biet, Samantha M., Simpson, Stephen J., Berthoud, Hans-Rudolf, Munzberg, Heike, Morrison, Christopher D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579533/
https://ncbi.nlm.nih.gov/pubmed/31167139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.022
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