FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor bKlotho (Klb) from the brain produces mice that are unable to mount a physiological response t...

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Udgivet i:Cell Rep
Main Authors: Hill, Cristal M., Laeger, Thomas, Dehner, Madeleine, Albarado, Diana C., Clarke, Blaise, Wanders, Desiree, Burke, Susan J., Collier, J. Jason, Qualls-Creekmore, Emily, Solon-Biet, Samantha M., Simpson, Stephen J., Berthoud, Hans-Rudolf, Munzberg, Heike, Morrison, Christopher D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579533/
https://ncbi.nlm.nih.gov/pubmed/31167139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.022
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