Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter

Mutations in the Plasmodium falciparum ‘chloroquine resistance transporter’ (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transport these drugs away from their targets within the parasite’s digestive vacuole (DV). However, CQ resistance-conferring...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Richards, Sashika N., Nash, Megan N., Baker, Eileen S., Webster, Michael W., Lehane, Adele M., Shafik, Sarah H., Martin, Rowena E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956231/
https://ncbi.nlm.nih.gov/pubmed/27441371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005725
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