Saquinavir Inhibits the Malaria Parasite's Chloroquine Resistance Transporter

The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations. Moreover, it has been reported that these APIs potentiate the activity of chloroquine (CQ) against this...

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Detalhes bibliográficos
Main Authors: Martin, Rowena E., Butterworth, Alice S., Gardiner, Donald L., Kirk, Kiaran, McCarthy, James S., Skinner-Adams, Tina S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346596/
https://ncbi.nlm.nih.gov/pubmed/22354298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00166-12
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