Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

The Hsp90 chaperone is a central node of protein homeostasis activating a large number of diverse client proteins. Hsp90 functions as a molecular clamp that closes and opens in response to the binding and hydrolysis of ATP. Crystallographic studies define distinct conformational states of the mechan...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Schulze, Andrea, Beliu, Gerti, Helmerich, Dominic A., Schubert, Jonathan, Pearl, Laurence H., Prodromou, Chrisostomos, Neuweiler, Hannes
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955915/
https://ncbi.nlm.nih.gov/pubmed/27322067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2111
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