AP endonuclease 1 prevents the extension of a T/G mismatch by DNA polymerase β to prevent mutations in CpGs during base excision repair

Dynamics of DNA methylation and demethylation at CpG clusters are involved in gene regulation. CpG clusters have been identified as hot spots of mutagenesis because of their susceptibility to oxidative DNA damage. Damaged Cs and Gs at CpGs can disrupt a normal DNA methylation pattern through modulat...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Lai, Yanhao, Jiang, Zhongliang, Zhou, Jing, Osemota, Emmanuel, Liu, Yuan
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955847/
https://ncbi.nlm.nih.gov/pubmed/27183823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.03.006
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