[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1

Analogues of [Dmt(1)]DALDA (H-Dmt-d-Arg-Phe-Lys-NH(2); Dmt = 2′,6′-dimethyltyrosine), a potent μ opioid agonist peptide with mitochondria-targeted antioxidant activity were prepared by replacing Dmt with various 2′,6′-dialkylated Tyr analogues, including 2′,4′,6′-trimethyltyrosine (Tmt), 2′-ethyl-6′...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Cai, Yunxin, Lu, Dandan, Chen, Zhen, Ding, Yi, Chung, Nga N., Li, Tingyou, Schiller, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955775/
https://ncbi.nlm.nih.gov/pubmed/27301366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.06.003
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