[Dmt(1)]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile

Analogues of [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2′,6′-dimethyltyrosine), a potent μ opioid agonist peptide with mitochondria-targeted antioxidant activity, were prepared by replacing Phe(3) with various 2′,6′-dialkylated Phe analogues, including 2′,6′-dimethylphenylalanine (Dmp), 2′4′,6...

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Bibliografiske detaljer
Main Authors: Bai, Longxiang, Li, Ziyuan, Chen, Jiajia, Chung, Nga N., Wilkes, Brian C., Li, Tingyou, Schiller, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980457/
https://ncbi.nlm.nih.gov/pubmed/24602401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.02.011
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