In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues

[Image: see text] In this study the μ opioid receptor (MOR) ligands DALDA (Tyr-d-Arg-Phe-Lys-NH(2)) and Dmt(1)-DALDA (Dmt-d-Arg-Phe-Lys-NH(2), Dmt = 2′,6′-dimethyltyrosine) were glycosylated at the N- or C-terminus. Subsequently, the modified peptides were subjected to in vitro and in vivo evaluatio...

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Hauptverfasser: Ballet, Steven, Betti, Cecilia, Novoa, Alexandre, Tömböly, Csaba, Uhd Nielsen, Carsten, Helms, Hans Christian, Lesniak, Anna, Kleczkowska, Patrycja, Chung, Nga N., Lipkowski, Andrzej W., Brodin, Birger, Tourwé, Dirk, Schiller, Peter W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023695/
https://ncbi.nlm.nih.gov/pubmed/24839540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4004765
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