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Tolerance develops in spinal cord, but not in brain with chronic [Dmt(1)]DALDA treatment

1. Previously, we reported that H-2′,6′-dimethyltyrosine [Dmt(1)]-D-Arg-Phe-Lys-NH(2) (DALDA), an analogue of the naturally occurring opioid peptide dermorphin, is a highly potent and selective mu receptor agonist with low cross-tolerance to morphine. In the present study, we investigated the effect...

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Main Authors: Ben, Yong, Smith, Andrew P, Schiller, Peter W, Lee, Nancy M
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575960/
https://ncbi.nlm.nih.gov/pubmed/15557286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706007
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