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Characterization of analgesic actions of the chronic intrathecal infusion of DMT-DALDA in rat

OBJECTIVES: DMT-DALDA (H-Dmt-D-Arg-Phe-Lys-NH2; Dmt=2’,6’-dimethyltyrosine) is a selective mu opioid agonist. We sought to characterize efficacy, tolerance, dependence and side effect profile when given by continuous intrathecal infusion. METHODS: Adult male Sprague Dawley rats were prepared with ch...

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Detalhes bibliográficos
Publicado no:Neuromodulation
Main Authors: Kokubu, Shinichi, Eddinger, Kelly A., Yamaguchi, Shigeki, Huerta-Esquivel, Lena Libertad, Schiller, Peter W., Yaksh, Tony L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706328/
https://ncbi.nlm.nih.gov/pubmed/30794333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ner.12925
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