Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog

BACKGROUND. We determined whether intrathecally delivering the same daily dose of morphine (MS) at a fixed concentration of 25 mg/mL by periodic boluses versus continuous infusion would reduce intrathecal mass (IMs) formation in dogs. METHODS. Adult dogs (hound cross, n = 32) were implanted with int...

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Опубликовано в: :Neuromodulation
Главные авторы: Hildebrand, Keith R., Page, Linda M., Billstrom, Tina M., Steinauer, Joanne J., Eddinger, Kelly A., Arjomand, Shervin, Yaksh, Tony L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803019/
https://ncbi.nlm.nih.gov/pubmed/31124198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ner.12963
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