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Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C*03:04 and modulate NK cell function

BACKGROUND & AIMS: Both NK cells and HLA/KIR interactions have been shown to play an important role in the control, clearance and progression of HCV disease. Here we aimed at elucidating the effects of viral peptides derived from HCV on HLA stabilization, changes in KIR binding and primary NK ce...

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Foilsithe in:J Hepatol
Main Authors: Lunemann, Sebastian, Martrus, Gloria, Hölzemer, Angelique, Chapel, Anais, Ziegler, Maja, Körner, Christian, Beltran, Wilfredo Garcia, Carrington, Mary, Wedemeyer, Heiner, Altfeld, Marcus
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955726/
https://ncbi.nlm.nih.gov/pubmed/27057987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.03.016
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