Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA- C*03:04 and modulate primary NK cell function

OBJECTIVE: The aim of this study was to assess the consequence of sequence variations in HLA-C*03:04-presented HIV-1 p24 Gag epitopes on binding of the inhibitory NK cell receptor KIR2DL2 to HLA-C*03:04. DESIGN: HIV-1 may possibly evade recognition by KIR+ NK cells through selection of sequence vari...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:AIDS
Auteurs principaux: VAN TEIJLINGEN, Nienke H., HÖLZEMER, Angelique, RNER, Christian K, GARCÍA-BELTRÁN, Wilfredo F., SCHAFER, Jamie, FADDA, Lena, SUSCOVICH, Todd, BRANDER, Christian, CARRINGTON, Mary, EVANS, David T., VAN BAARLE, Debbie, ALTFELD, Marcus
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453925/
https://ncbi.nlm.nih.gov/pubmed/24785948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000284
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires