Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C*03:04 and modulate NK cell function

BACKGROUND & AIMS: Both NK cells and HLA/KIR interactions have been shown to play an important role in the control, clearance and progression of HCV disease. Here we aimed at elucidating the effects of viral peptides derived from HCV on HLA stabilization, changes in KIR binding and primary NK ce...

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Publicado no:J Hepatol
Main Authors: Lunemann, Sebastian, Martrus, Gloria, Hölzemer, Angelique, Chapel, Anais, Ziegler, Maja, Körner, Christian, Beltran, Wilfredo Garcia, Carrington, Mary, Wedemeyer, Heiner, Altfeld, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955726/
https://ncbi.nlm.nih.gov/pubmed/27057987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.03.016
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