HIV-1 Evades a Gag Mutation that Abrogates KIR Binding and Disinhibits NK Cells in Infected Individuals with KIR2DL2(+)/HLA-C*03:04(+) Genotype

HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leucocyte class I (HLA-I) molecules modulating NK cell function. HIV-1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in ind...

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Publicado no:AIDS
Main Authors: Ziegler, Maja C., Naidoo, Kewreshini, Chapel, Anais, Nkotwana, Sindiswa, Mann, Jaclyn, Mncube, Zenele, Ismael, Nasreen, Goulder, Philip, Ndung’u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856308/
https://ncbi.nlm.nih.gov/pubmed/33273184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002721
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