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HIV-1 Evades a Gag Mutation that Abrogates KIR Binding and Disinhibits NK Cells in Infected Individuals with KIR2DL2(+)/HLA-C*03:04(+) Genotype
HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leucocyte class I (HLA-I) molecules modulating NK cell function. HIV-1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in ind...
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| Pubblicato in: | AIDS |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7856308/ https://ncbi.nlm.nih.gov/pubmed/33273184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002721 |
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