Control of the innate immune response by the mevalonate pathway

Deficiency of mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate (GGPP), a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylat...

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Pubblicato in:Nat Immunol
Autori principali: Akula, Murali K., Shi, Man, Jiang, Zhaozhao, Foster, Celia E., Miao, David, Li, Annie S., Zhang, Xiaoman, Gavin, Ruth M., Forde, Sorcha D., Germain, Gail, Carpenter, Susan, Rosadini, Charles V., Gritsman, Kira, Chae, Jae Jin, Hampton, Randolph, Silverman, Neal, Gravallese, Ellen M., Kagan, Jonathan C., Fitzgerald, Katherine A., Kastner, Daniel L., Golenbock, Douglas T., Bergo, Martin O., Wang, Donghai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955724/
https://ncbi.nlm.nih.gov/pubmed/27270400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3487
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