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Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding

Single amino acid variations (SAV) occurring in human population result in natural differences between individuals or cause diseases. It is well understood that the molecular effect of SAV can be manifested as changes of the wild type characteristics of the corresponding protein, among which are the...

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Bibliografiske detaljer
Udgivet i:Proteins
Main Authors: Peng, Yunhui, Alexov, Emil
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955551/
https://ncbi.nlm.nih.gov/pubmed/26650512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24968
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