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Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding

Single amino acid variations (SAV) occurring in human population result in natural differences between individuals or cause diseases. It is well understood that the molecular effect of SAV can be manifested as changes of the wild type characteristics of the corresponding protein, among which are the...

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Dettagli Bibliografici
Pubblicato in:Proteins
Autori principali: Peng, Yunhui, Alexov, Emil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955551/
https://ncbi.nlm.nih.gov/pubmed/26650512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24968
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