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Structural Assessment of the Effects of Amino Acid Substitutions on Protein Stability and Protein-Protein Interaction
A structure-based approach is described for predicting the effects of amino acid substitutions on protein function. Structures were predicted using a homology modelling method. Folding and binding energy differences between wild-type and mutant structures were computed to quantitatively assess the e...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319068/ https://ncbi.nlm.nih.gov/pubmed/21297231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1504/IJCBDD.2010.038396 |
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