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Modeling Effects of Human Single Nucleotide Polymorphisms on Protein-Protein Interactions
A large set of three-dimensional structures of 264 protein-protein complexes with known nonsynonymous single nucleotide polymorphisms (nsSNPs) at the interface was built using homology-based methods. The nsSNPs were mapped on the proteins' structures and their effect on the binding energy was i...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717281/ https://ncbi.nlm.nih.gov/pubmed/19289044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3904 |
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