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Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients
Adverse reactions and non-response are common in patients treated with thiopurine drugs. Current monitoring of drug metabolite levels for guiding treatment are limited to analysis of thioguanine nucleotides (TGNs) in erythrocytes after chemical derivatisation. Erythrocytes are not the target tissue...
Gespeichert in:
| Veröffentlicht in: | J Chromatogr B Analyt Technol Biomed Life Sci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955110/ https://ncbi.nlm.nih.gov/pubmed/27362994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.06.017 |
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