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Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients

Adverse reactions and non-response are common in patients treated with thiopurine drugs. Current monitoring of drug metabolite levels for guiding treatment are limited to analysis of thioguanine nucleotides (TGNs) in erythrocytes after chemical derivatisation. Erythrocytes are not the target tissue...

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Bibliografski detalji
Izdano u:J Chromatogr B Analyt Technol Biomed Life Sci
Glavni autori: Coulthard, Sally A., Berry, Phil, McGarrity, Sarah, Ansari, Azhar, Redfern, Christopher P.F.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955110/
https://ncbi.nlm.nih.gov/pubmed/27362994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.06.017
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