Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients

Adverse reactions and non-response are common in patients treated with thiopurine drugs. Current monitoring of drug metabolite levels for guiding treatment are limited to analysis of thioguanine nucleotides (TGNs) in erythrocytes after chemical derivatisation. Erythrocytes are not the target tissue...

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Vydáno v:J Chromatogr B Analyt Technol Biomed Life Sci
Hlavní autoři: Coulthard, Sally A., Berry, Phil, McGarrity, Sarah, Ansari, Azhar, Redfern, Christopher P.F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955110/
https://ncbi.nlm.nih.gov/pubmed/27362994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.06.017
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