Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

The pharmacokinetics of small interfering RNAs (siRNAs) is a pivotal issue for siRNA-based drug development. In this study, we comprehensively investigated the behavior of siRNAs in vivo in various tissues and demonstrated that intravenously-injected naked siRNA accumulated remarkably in the submand...

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Podrobná bibliografie
Vydáno v:Theranostics
Hlavní autoři: Huang, Yuanyu, Cheng, Qiang, Ji, Jia-Li, Zheng, Shuquan, Du, Lili, Meng, Lingwei, Wu, Yidi, Zhao, Deyao, Wang, Xiaoxia, Lai, Li, Cao, Huiqing, Xiao, Kai, Gao, Shan, Liang, Zicai
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955053/
https://ncbi.nlm.nih.gov/pubmed/27446488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15246
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