Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

The pharmacokinetics of small interfering RNAs (siRNAs) is a pivotal issue for siRNA-based drug development. In this study, we comprehensively investigated the behavior of siRNAs in vivo in various tissues and demonstrated that intravenously-injected naked siRNA accumulated remarkably in the submand...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Huang, Yuanyu, Cheng, Qiang, Ji, Jia-Li, Zheng, Shuquan, Du, Lili, Meng, Lingwei, Wu, Yidi, Zhao, Deyao, Wang, Xiaoxia, Lai, Li, Cao, Huiqing, Xiao, Kai, Gao, Shan, Liang, Zicai
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955053/
https://ncbi.nlm.nih.gov/pubmed/27446488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15246
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